Janssen Pharmaceutica N.V., Janssen L.P., and Synaptech, Inc. (“Janssen”), appeal from a final judgment of the United States District Court for the District of Delaware. After a bench trial, the district court determined that the claims of U.S. Patent No. 4,663,318 (“the ’318 patent”) were invalid for lack of enablement. In re ’318 Patent Infringement Litig., 578 F. Supp. 2d 711, 737 (D. Del. 2008). We affirm.