Carnegie Mellon University (“CMU”) and Three Rivers Biologicals, Inc. (collectively “appellants”) appeal from the decision of the United States District Court for the Northern District of California holding that Hoffmann-La Roche, Inc., Roche Molecular Systems, Inc., Roche Diagnostic Systems, Inc., Roche Biomedical Laboratories, Inc., The Perkin Elmer Corporation, and Laboratory Corporation of America Holdings (collectively “Roche”) do not infringe the patents in suit and that certain claims are invalid for lack of written description. Because we conclude that the district court did not err in holding the claims invalid for failure to meet the written description requirement, we affirm the court’s judgment of invalidity. Because we conclude that the court did not err in its infringement analysis, we affirm the court’s judgment of noninfringement.